铁代谢与先天免疫对感染的反应。
Iron metabolism and the innate immune response to infection.
机构信息
John Carroll University, Department of Biology, 20700 North Park Boulevard, University Heights, OH 44118, USA.
出版信息
Microbes Infect. 2012 Mar;14(3):207-16. doi: 10.1016/j.micinf.2011.10.001. Epub 2011 Oct 20.
Abstract
Host antimicrobial mechanisms reduce iron availability to pathogens. Iron proteins influencing the innate immune response include hepcidin, lactoferrin, siderocalin, haptoglobin, hemopexin, Nramp1, ferroportin and the transferrin receptor. Numerous global health threats are influenced by iron status and provide examples of our growing understanding of the connections between infection and iron metabolism.
摘要
宿主的抗菌机制会降低病原体可利用的铁含量。影响先天免疫反应的铁蛋白包括铁调素、乳铁蛋白、转铁蛋白、结合珠蛋白、血红素结合蛋白、Nramp1、亚铁转运蛋白和转铁蛋白受体。许多全球性健康威胁都受到铁状态的影响，这些例子体现了我们对感染与铁代谢之间联系的理解不断加深。
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