Smyth L A, Witt C S, Christiansen F T, Herrmann R P, Hollingsworth P N, Townend D C, Edward E, Dawkins R L
Department of Clinical Immunology, Royal Perth Hospital, Australia.
Bone Marrow Transplant. 1993 Oct;12(4):351-5.
To determine whether the MHC plays an antigen non-specific role in the development of acute GVHD, the prevalence of acute GVHD in relation to MHC genotype was examined in 51 adult patients undergoing allogeneic BM grafting. The majority of patients received grafts from HLA-identical siblings. HLA-B7 haplotypes were associated with a decreased risk of acute GVHD (2 of 15, p = 0.005) whereas HLA-B44 haplotypes were associated with a higher risk of acute GVHD (11 of 14, p = 0.02). As these alleles have been reported previously as having opposite effects in relation to inflammatory mediators, these findings may have important implications with respect to donor selection and patient management.
为了确定主要组织相容性复合体（MHC）在急性移植物抗宿主病（GVHD）发生过程中是否发挥抗原非特异性作用，研究人员在51例接受同种异体骨髓移植的成年患者中，检测了与MHC基因型相关的急性GVHD患病率。大多数患者接受了来自人类白细胞抗原（HLA）相同同胞的移植物。HLA - B7单倍型与急性GVHD风险降低相关（15例中有2例，p = 0.005），而HLA - B44单倍型与急性GVHD风险较高相关（14例中有11例，p = 0.02）。由于这些等位基因先前已被报道在炎症介质方面具有相反的作用，这些发现可能对供体选择和患者管理具有重要意义。
