Dugan M J, Rouch D A, Akard L P, Sperl B G, Black J R, Markham R E, Jansen J
Department of Medical Education, Methodist Hospital, Indianapolis, IN 46206-1367.
Bone Marrow Transplant. 1993 Oct;12(4):417-419.
A 29-year-old male patient presented with acute liver failure from non-A, non-B and non-C hepatitis, necessitating orthotopic liver transplantation. After operation he developed progressive pancytopenia on the basis of aplastic anemia, which was probably hepatitis associated. After therapy with GM-CSF had failed, he underwent allogeneic BMT from his HLA genotypically identical brother following a conditioning regimen of CY 50 mg/kg x 4 and 500 cGy total lymphoid irradiation. He engrafted promptly but transfusion dependency did not resolve until CMV viremia was treated with ganciclovir. The patient is alive and well 2 years after BMT.
一名29岁男性患者因非甲、非乙、非丙型肝炎导致急性肝衰竭，需要进行原位肝移植。术后，他在再生障碍性贫血的基础上出现进行性全血细胞减少，这可能与肝炎相关。在粒细胞集落刺激因子治疗失败后，他在接受了环磷酰胺50mg/kg×4以及500cGy全身淋巴照射的预处理方案后，接受了来自其HLA基因完全相同的兄弟的异基因骨髓移植。他迅速植入，但直到用更昔洛韦治疗巨细胞病毒血症后输血依赖才得以解决。骨髓移植后2年，患者存活且状况良好。
