Rodriguez M, Martin L, Santana C
Department of Physiology, School of Medicine, University of La Laguna, Tenerife, Canary Islands, Spain.
Brain Res Bull. 1994;33(2):163-71. doi: 10.1016/0361-9230(94)90246-1.
In the present study the right-left brain asymmetry of central dopamine (DA) systems during postnatal brain development is evaluated. DA and dihydroxyphenylacetic acid (DOPAC) levels increased from neonatal to adult life in both the forebrain and mesencephalon. This increase was not similar in the right and left brain sides. From neonatal life to adulthood a fall was observed in (a) DA percentage in the DA high-brain side in the mesencephalon and (b) DOPAC percentage in the DOPAC high-brain side in both the forebrain and mesencephalon. The percentage of lateralized rats (more than 65% of DA or DOPAC levels in either brain side) also decreased during ontogeny. Thus, biochemical lateralization decreases during ontogeny. The right-left brain correlation for DA level and DA turnover was used to evaluate the inter-hemispheric regulation of dopaminergic systems. The correlation coefficient was near to 0 during postnatal life and around -0.8 during adulthood in both forebrain and mesencephalon. Taken together, these data suggest that the ontogenic decrease of in brain asymmetry for DA or DOPAC levels is related to the postnatal development of an inter-hemispheric regulatory system that control dopaminergic neurons activity.
在本研究中，对出生后脑发育过程中中枢多巴胺（DA）系统的左右脑不对称性进行了评估。在前脑和中脑，从新生儿期到成年期，多巴胺（DA）和二羟基苯乙酸（DOPAC）水平均升高。左右脑两侧的这种升高情况并不相同。从新生儿期到成年期，观察到：（a）中脑DA高脑侧的DA百分比下降；（b）前脑和中脑DOPAC高脑侧的DOPAC百分比下降。在个体发育过程中，偏侧化大鼠（任一侧脑的DA或DOPAC水平超过65%）的百分比也下降。因此，在个体发育过程中，生化偏侧化程度降低。利用DA水平和DA周转率的左右脑相关性来评估多巴胺能系统的半球间调节。在出生后生活中，相关系数接近0，而在成年期，在前脑和中脑均约为-0.8。综上所述，这些数据表明，DA或DOPAC水平的脑不对称性在个体发育过程中的降低与控制多巴胺能神经元活动的半球间调节系统的出生后发育有关。
