Irshaid Y M, al-Hadidi H F, Rawashdeh N M
Department of Pharmacology, Faculty of Medicine, University of Science and Technology, Irbid, Jordan.
Eur J Clin Pharmacol. 1993;45(3):271-3. doi: 10.1007/BF00315395.
The O-demethylation of dextromethorphan (DMT) to dextrorphan (DRP) was studied in 241 unrelated, healthy Jordanian volunteers (171 males, 70 females). Urine was collected for 8 h following a single oral dose of DMT bromhydrate 30 mg. A thin-layer chromatographic (TLC) technique was used to identify the metaboliser phenotype. The frequency of the poor metaboliser phenotype was found to be 2.9% (approximate 95% confidence interval 0.8-5.0%). Applying the Hardy-Weinberg Law, the frequency of the recessive autosomal gene controlling poor metabolism was 0.17 (95% confidence interval 0.108-0.232).
