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Defective oxidation of drugs: pharmacokinetic and therapeutic implications.

作者信息

Eichelbaum M

出版信息

Clin Pharmacokinet. 1982 Jan-Feb;7(1):1-22. doi: 10.2165/00003088-198207010-00001.

DOI:10.2165/00003088-198207010-00001
PMID:7042170
Abstract
摘要

相似文献

1
Defective oxidation of drugs: pharmacokinetic and therapeutic implications.药物氧化缺陷：药代动力学及治疗学意义
Clin Pharmacokinet. 1982 Jan-Feb;7(1):1-22. doi: 10.2165/00003088-198207010-00001.
2
Polymorphic drug oxidation in humans.人类的多态性药物氧化
Fed Proc. 1984 May 15;43(8):2298-302.
3
[Genetic polymorphism of oxidative drug metabolism. Therapeutic and toxicologic implications].[氧化药物代谢的基因多态性。治疗和毒理学意义]
Internist (Berl). 1983 Mar;24(3):117-27.
4
Genetic polymorphism of drug metabolism in humans.人类药物代谢的基因多态性
Adv Exp Med Biol. 1991;283:627-40. doi: 10.1007/978-1-4684-5877-0_79.
5
Genetically determined polymorphisms in drug oxidation.
Hepatology. 1986 Sep-Oct;6(5):1020-32. doi: 10.1002/hep.1840060534.
6
Polymorphisms of oxidation at carbon centers of drugs and their clinical significance.药物碳中心氧化的多态性及其临床意义。
Drug Metab Rev. 1979;9(2):301-17. doi: 10.3109/03602537908993896.
7
Application of the phenotyped panel approach to the detection of polymorphism of drug oxidation in man [proceedings].表型分组方法在检测人体药物氧化多态性中的应用[会议论文集]
Br J Pharmacol. 1979 Jul;66(3):430P-431P.
8
Pharmacogenetic polymorphism of drug metabolism.
N Z Med J. 1984 Aug 22;97(762):567-9.
9
Ethnic differences in reactions to drugs and xenobiotics. Therapy.药物和外源性物质反应中的种族差异。治疗。
Prog Clin Biol Res. 1986;214:491-526.
10
Genetically determined variability in acetylation and oxidation. Therapeutic implications.乙酰化和氧化的基因决定变异性。治疗意义。
Drugs. 1985 Apr;29(4):342-75. doi: 10.2165/00003495-198529040-00003.

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Cytochrome P450 enzymes and drug metabolism--basic concepts and methods of assessment.细胞色素P450酶与药物代谢——评估的基本概念和方法
Cell Mol Neurobiol. 1999 Jun;19(3):309-23. doi: 10.1023/a:1006993631057.
2
Lack of association between glucose-6-phosphate dehydrogenase deficiency and dextromethorphan O-demethylation polymorphism.葡萄糖-6-磷酸脱氢酶缺乏症与右美沙芬O-去甲基化多态性之间不存在关联。
Eur J Clin Pharmacol. 1993;44(3):303-4. doi: 10.1007/BF00271379.
3
Dextromethorphan O-demethylation polymorphism in Jordanians.

本文引用的文献

1
The fate of acetophenetidin in man and methods for the estimation of acetophenetidin and its metabolites in biological material.非那西丁在人体中的代谢情况以及生物材料中非那西丁及其代谢产物的测定方法。
J Pharmacol Exp Ther. 1949 Sep;97(1):58-67.
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THE PHYSIOLOGICAL BASIS OF CARDIAC ARRHYTHMIAS.心律失常的生理基础
Am J Med. 1964 Nov;37:670-84. doi: 10.1016/0002-9343(64)90017-8.
3
INSUFFICIENT PARAPHYDROXYLATION AS A CAUSE OF DIPHENYLHYDANTOIN TOXICITY.羟化不足作为苯妥英钠毒性的一个原因
Eur J Clin Pharmacol. 1993;45(3):271-3. doi: 10.1007/BF00315395.
4
Individual variation in first-pass metabolism.首过代谢的个体差异。
Clin Pharmacokinet. 1993 Oct;25(4):300-28. doi: 10.2165/00003088-199325040-00005.
5
Polymorphism in the metabolism of drugs, including antidepressant drugs: comments on phenotyping.药物代谢中的多态性，包括抗抑郁药物：关于表型分析的评论
J Psychiatry Neurosci. 1994 Jan;19(1):30-44.
6
Role of oxidation polymorphism on blood and urine concentrations of amitriptyline and its metabolites in man.氧化多态性对人体内阿米替林及其代谢产物血药浓度和尿药浓度的作用。
Arch Psychiatr Nervenkr (1970). 1982;232(3):215-22. doi: 10.1007/BF02141782.
7
Antipyrine metabolism in relation to polymorphic oxidations of sparteine and debrisoquine.安替比林代谢与司巴丁和异喹胍多态性氧化的关系。
Br J Clin Pharmacol. 1983 Mar;15(3):317-21. doi: 10.1111/j.1365-2125.1983.tb01505.x.
8
Urinary bile acid and bile alcohol excretion does not reflect the genetic polymorphism of debrisoquine hydroxylation.尿胆汁酸和胆汁醇排泄不能反映异喹胍羟基化的遗传多态性。
Br J Clin Pharmacol. 1984 Apr;17(4):470-3. doi: 10.1111/j.1365-2125.1984.tb02374.x.
9
Interindividual variations in drug disposition. Clinical implications and methods of investigation.药物处置的个体间差异。临床意义及研究方法。
Clin Pharmacokinet. 1983 Sep-Oct;8(5):371-7. doi: 10.2165/00003088-198308050-00001.
10
Characterization of a human liver cytochrome P-450 involved in the oxidation of debrisoquine and other drugs by using antibodies raised to the analogous rat enzyme.通过使用针对类似大鼠酶产生的抗体来鉴定参与异喹胍和其他药物氧化的人肝脏细胞色素P-450。
Proc Natl Acad Sci U S A. 1984 Dec;81(23):7348-52. doi: 10.1073/pnas.81.23.7348.
Neurology. 1964 Jun;14:542-8. doi: 10.1212/wnl.14.6.542.
4
Nortriptyline and antipyrine clearance in relation to debrisoquine hydroxylation in man.人体内去甲替林和安替比林清除率与异喹胍羟化作用的关系。
Life Sci. 1980 Nov 3;27(18):1673-7. doi: 10.1016/0024-3205(80)90642-6.
5
A family and population study of the genetic polymorphism of debrisoquine oxidation in a white British population.对英国白人人群中异喹胍氧化遗传多态性的家系及群体研究。
J Med Genet. 1980 Apr;17(2):102-5. doi: 10.1136/jmg.17.2.102.
6
Pharmacogenetic covariation of defective N-oxidation of sparteine and 4-hydroxylation of debrisoquine.司巴丁N-氧化缺陷与异喹胍4-羟化的药物遗传学共变。
Eur J Clin Pharmacol. 1980 Feb;17(2):153-5. doi: 10.1007/BF00562624.
7
Deficient metabolism of debrisoquine and sparteine.异喹胍和鹰爪豆碱代谢缺陷。
Clin Pharmacol Ther. 1980 Apr;27(4):547-9. doi: 10.1038/clpt.1980.77.
8
Inheritance of phenytoin hypometabolism: a kinetic study of one family.
Clin Pharmacol Ther. 1980 Jan;27(1):96-103. doi: 10.1038/clpt.1980.15.
9
Tolbutamide, smoking, and cardiac arrhythmia. A case report.甲苯磺丁脲、吸烟与心律失常。病例报告。
JAMA. 1980;244(8):811-2.
10
Genetic impairment of phenformin metabolism.苯乙双胍代谢的基因损伤。
Lancet. 1980 May 24;1(8178):1147. doi: 10.1016/s0140-6736(80)91604-9.