人类白细胞抗原DR4是原发性硬化性胆管炎疾病快速进展的一个标志物。
HLA DR4 is a marker for rapid disease progression in primary sclerosing cholangitis.
作者信息
Mehal W Z, Lo Y M, Wordsworth B P, Neuberger J M, Hubscher S C, Fleming K A, Chapman R W
机构信息
Nuffield Department of Pathology and Bacteriology, John Radcliffe Hospital, Oxford, England.
出版信息
Gastroenterology. 1994 Jan;106(1):160-7. doi: 10.1016/s0016-5085(94)95085-7.
BACKGROUND/AIMS: Primary sclerosing cholangitis (PSC) is an inflammatory disease of the biliary tree associated with an increase in the HLA alleles DR3, DR52a, DR2, Dw2, and a decrease in DR4. However, it is not certain which of these alleles provides the primary associations. Our aim was to establish the primary HLA associations with PSC and to assess the ability of HLA alleles to mark for disease progression.
METHODS
By applying molecular techniques to archival tissue, we have genotyped 83 PSC patients from two populations and 131 controls for the alleles HLA DR2, DR3, DR4, DRw12, DR52a, and Dw2.
RESULTS
HLA DR3, DR52a, DR2, and Dw2 were all significantly increased in PSC, with the relative risk for DR52a and Dw2 being greater than for DR3 and DR2, respectively. HLA DR4 was significantly decreased, but this may be artifactual to the DR3, DR2 increase. HLA DR4 and not DR52a marks for rapid disease progression in both our PSC populations.
CONCLUSIONS
HLA DR52a and Dw2 are the best candidate alleles for providing the known HLA association with PSC. HLA DR4 and not DR52a marks for rapid disease progression in our two PSC populations.
背景/目的：原发性硬化性胆管炎（PSC）是一种胆管树的炎症性疾病，与HLA等位基因DR3、DR52a、DR2、Dw2增加以及DR4减少有关。然而，尚不确定这些等位基因中哪些提供主要关联。我们的目的是确定与PSC相关的主要HLA关联，并评估HLA等位基因标记疾病进展的能力。
方法
通过对存档组织应用分子技术，我们对来自两个群体的83例PSC患者和131例对照进行了HLA DR2、DR3、DR4、DRw12、DR52a和Dw2等位基因的基因分型。
结果
PSC患者中HLA DR3、DR52a、DR2和Dw2均显著增加，DR52a和Dw2的相对风险分别大于DR3和DR2。HLA DR4显著降低，但这可能是DR3、DR2增加的假象。在我们的两个PSC群体中，HLA DR4而非DR52a标记疾病快速进展。
结论
HLA DR52a和Dw2是与PSC已知HLA关联的最佳候选等位基因。在我们的两个PSC群体中，HLA DR4而非DR52a标记疾病快速进展。
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