Silver L M, Buck C
Department of Molecular Biology, Princeton University, NJ 08544-1014.
Genet Res. 1993 Oct;62(2):133-7. doi: 10.1017/s0016672300031724.
A novel central partial t haplotype was generated by screening for a recombination event between overlapping distal and proximal partial haplotypes. This haplotype contains just two elements--Tcrt and Tcd-3t--involved in the t-specific transmission ratio distortion phenotype. Breeding analysis of males that carry this chromosome provides evidence that Tcd-3 is, indeed, a distorter locus and not a second responder. Furthermore, the data indicate that a single well-defined distorter locus is insufficient to overcome completely the self-destructive, low transmission ratio distortion phenotype expressed by the t allele at the t complex responder locus, although a small, but highly significant, effect was observed.
通过筛选重叠的远端和近端部分单倍型之间的重组事件，产生了一种新的中央部分t单倍型。这种单倍型仅包含两个与t特异性传递比率畸变表型有关的元件——Tcrt和Tcd-3t。对携带这条染色体的雄性进行育种分析，结果表明Tcd-3确实是一个畸变位点，而非第二个响应位点。此外，数据表明，尽管观察到了微小但高度显著的效应，但一个明确的畸变位点不足以完全克服t复合响应位点处t等位基因所表现出的自我破坏、低传递比率畸变表型。
