Monreal M, Galego G, Monreal L, Angles A M, Monasterio J, Oller B
Experimental Unit on Thrombosis, Universidad Autónoma de Barcelona, Spain.
Haemostasis. 1993 May-Jun;23(3):179-83. doi: 10.1159/000216872.
In a random, blind study, we compared the antithrombotic potential of unfractioned heparin, a low-molecular weight heparin (LMWH) and a recombinant hirudin (r-hirudin) given subcutaneously in a jugular vein thrombosis model in rabbits. All drugs and placebo were injected subcutaneously 2 h before inducing experimental thrombosis. A good thromboprophylactic effect was obtained with either LMWH and r-hirudin as compared with placebo. By contrast, no significant differences were found between groups in bleeding time. We also found a small (non-significant) prolongation of the activated partial thromboplastin time in the r-hirudin-treated animals. As for thrombin time, r-hirudin-treated rabbits exhibited too much sensitivity, with noncoagulable end-points. In our study, r-hirudin at the dose used seemed to be as effective as LMWH is in the prophylaxis of venous thrombosis.
在一项随机、盲法研究中，我们在兔颈静脉血栓形成模型中比较了皮下给予普通肝素、低分子量肝素（LMWH）和重组水蛭素（r-水蛭素）的抗血栓形成潜力。在诱导实验性血栓形成前2小时，将所有药物和安慰剂皮下注射。与安慰剂相比，LMWH和r-水蛭素均获得了良好的血栓预防效果。相比之下，各组之间的出血时间未发现显著差异。我们还发现r-水蛭素治疗的动物活化部分凝血活酶时间有轻微（无统计学意义）延长。至于凝血酶时间，r-水蛭素治疗的兔表现出过度敏感，出现不可凝固的终点。在我们的研究中，所用剂量的r-水蛭素在预防静脉血栓形成方面似乎与LMWH一样有效。
