Talwar D, Jindal S K
Department of Pulmonary Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh.
Indian J Physiol Pharmacol. 1993 Jul;37(3):217-20.
To assess the effects of enalapril on bronchial responsiveness, we studied ten stable asthmatics and five healthy normal volunteers. Spirometry and methacholine bronchoprovocation dose (PC20) were measured before and after oral administration of 20 mg enalapril. Significant hypotensive effect was observed in all. More than two fold (2.73) increase in bronchial responsiveness was observed in the asthmatics (P < 0.01) without significant change in the expiratory flows. PC20 after enalapril fell by 56.8 +/- 23.0% of baseline value (P < 0.001). No significant change was observed in spirometric parameters and bronchial responsiveness in normal subjects. We conclude that enalapril significantly enhances BR and cannot be used safely in treatment of hypertension in asthmatics.
为评估依那普利对支气管反应性的影响，我们研究了10名病情稳定的哮喘患者和5名健康正常志愿者。在口服20毫克依那普利前后，测量了肺活量和乙酰甲胆碱支气管激发剂量（PC20）。所有人均观察到显著的降压效果。哮喘患者的支气管反应性增加了两倍多（2.73倍）（P < 0.01），而呼气流量无显著变化。依那普利治疗后的PC20下降至基线值的56.8 +/- 23.0%（P < 0.001）。正常受试者的肺活量参数和支气管反应性未观察到显著变化。我们得出结论，依那普利可显著增强支气管反应性，不能安全地用于哮喘患者高血压的治疗。
