Grover J K, Tyagi D
Department of Pharmacology, All-India Institute of Medical Sciences, New Delhi.
Indian J Physiol Pharmacol. 1993 Jul;37(3):247-8.
The overall incidence of adverse drug reactions following ampicillin and amoxicillin administration to 439 and 169 indoor patients of All India Institute of Medical Sciences, New Delhi were 19.13% and 15.5% respectively. Ampicillin produced diarrhoea (7.74%), nausea and vomiting (7.74%) anorexia (5.46%) headache (4.10%) and allergic reactions (2.9%). With amoxicillin, anorexia was observed in 4.79%, epigastric distress in 5.9% headache in 6.58%, coating of tongue in 8.98% and dizziness in 1.79% of patients. Intramuscular route of administration of ampicillin produced least ADRs. Females were more susceptible to adverse reactions of ampicillin and males to amoxicillin. Incidence of ADRs by these two aminopenicillins is less than that reported from abroad.
在新德里全印度医学科学研究所，对439名和169名住院患者分别给予氨苄西林和阿莫西林后，药物不良反应的总体发生率分别为19.13%和15.5%。氨苄西林引起腹泻（7.74%）、恶心和呕吐（7.74%）、厌食（5.46%）、头痛（4.10%）和过敏反应（2.9%）。使用阿莫西林时，观察到4.79%的患者出现厌食，5.9%的患者出现上腹部不适，6.58%的患者出现头痛，8.98%的患者出现舌苔，1.79%的患者出现头晕。氨苄西林的肌内注射给药途径产生的药物不良反应最少。女性更容易出现氨苄西林的不良反应，而男性更容易出现阿莫西林的不良反应。这两种氨基青霉素的药物不良反应发生率低于国外报道的发生率。
