Husain K, Kumar P, Vijayaraghavan R, Singh R, Das Gupta S
Division of Pharmacology and Toxicology, Defence R & D Establishment, Gwalior.
Indian J Physiol Pharmacol. 1993 Jul;37(3):249-51.
The effect of pretreatment of two carbamates, pyridostigmine and physostigmine on dynamic pulmonary mechanics has been studied in rats exposed to sarin aerosols. Sign-free dose of pyridostigmine (0.075 mg/kg, i.m.) or physostigmine (0.1 mg/kg, i.m.) did not significantly alter the parameters of the dynamic pulmonary mechanics 20 min after treatment. However, sarin (51.2 mg/m3, for 15 min) depressed the respiratory rate, air flow and minute volume and enhanced the transthoracic pressure and tidal volume. Pretreatment with carbamates 20 min prior to sarin exposure significantly modified or counteracted the above induced changes. It is concluded that the protective effect of carbamates is mainly due to the correction of respiratory changes caused by sarin aerosols in rats.
在暴露于沙林气雾剂的大鼠中，研究了两种氨基甲酸酯类药物（吡啶斯的明和毒扁豆碱）预处理对动态肺力学的影响。无显著作用剂量的吡啶斯的明（0.075毫克/千克，肌肉注射）或毒扁豆碱（0.1毫克/千克，肌肉注射）在治疗后20分钟未显著改变动态肺力学参数。然而，沙林（51.2毫克/立方米，持续15分钟）降低了呼吸频率、气流和分钟通气量，并增加了跨胸压和潮气量。在暴露于沙林前20分钟用氨基甲酸酯类药物预处理可显著改变或抵消上述诱导变化。得出的结论是，氨基甲酸酯类药物的保护作用主要是由于纠正了大鼠沙林气雾剂引起的呼吸变化。
