Ozaki O, Ito K, Sugino K
Department of Surgery, Ito Hospital, Tokyo, Japan.
Int Surg. 1993 Jul-Sep;78(3):218-20.
From 1952 to 1984, 70 primary cases of differentiated thyroid carcinoma with pulmonary metastasis were treated. Of these, histopathological sections were reviewed in 59 cases (metastasis group). Fifty-nine age-, sex- and histology-matched cases without pulmonary metastasis were chosen as controls (control group). Poorly differentiated features of tumor cells were observed in 57.6% of the cases in the metastasis group but in only 27.1% of the control group (P < 0.001). In contrast, solid and/or trabecular growth patterns were noted in 45.8% of the cases in the metastasis group and 52.5% of the control group (P > 0.30). No difference in the incidence of vascular or capsular invasion was seen between the two groups. These findings suggest that the poorly differentiated features of tumor cells rather than the solid and/or trabecular growth pattern or vascular invasion of the tumor are more important as histopathologic characteristics of differentiated thyroid carcinoma with pulmonary metastasis.
1952年至1984年期间，共治疗了70例原发性分化型甲状腺癌伴肺转移患者。其中，对59例患者（转移组）的组织病理学切片进行了复查。选取59例年龄、性别和组织学相匹配且无肺转移的患者作为对照组。转移组中57.6%的病例观察到肿瘤细胞分化差的特征，而对照组中仅为27.1%（P<0.001）。相反，转移组45.8%的病例以及对照组52.5%的病例观察到实性和/或小梁状生长模式（P>0.30）。两组间血管或包膜侵犯的发生率无差异。这些发现表明，肿瘤细胞的低分化特征而非肿瘤的实性和/或小梁状生长模式或血管侵犯，作为分化型甲状腺癌伴肺转移的组织病理学特征更为重要。
