Takami H, Kodaira S
First Department of Surgery, Teikyo University School of Medicine, Tokyo, Japan.
Int Surg. 1993 Jul-Sep;78(3):225-8.
The authors report four unusual cases of clinically occult carcinoma of the thyroid. Exploratory excision of osseous metastatic lesions was performed for diagnosis in Patients 1 and 2, and fine needle aspiration of cervical metastatic lesions was used for diagnosis in Patients 3 and 4. A definite diagnosis of thyroid cancer could not be made by hematoxylin and eosin staining in Patient 2, nor by fine needle aspiration in Patient 3. However, the diagnosis of thyroid cancer in both patients was made using the rapid immunoperoxidase method with an antibody against thyroglobulin. The rapid immunoperoxidase method reported in this paper requires only about 5 minutes. Hence, this rapid staining method may be routinely applied to definitive identification of the thyroid as the source of metastatic lesions, prior to surgery.
作者报告了4例临床隐匿性甲状腺癌的罕见病例。对1号和2号患者进行了骨转移灶的探查性切除以明确诊断，对3号和4号患者采用了颈部转移灶的细针穿刺进行诊断。2号患者经苏木精-伊红染色无法明确诊断甲状腺癌，3号患者经细针穿刺也无法确诊。然而，这两名患者均采用抗甲状腺球蛋白抗体的快速免疫过氧化物酶法确诊为甲状腺癌。本文报道的快速免疫过氧化物酶法仅需约5分钟。因此，这种快速染色方法可在术前常规用于明确甲状腺是否为转移灶的来源。
