Dawson P, Peters M
Royal Postgraduate Medical School, London, England.
Invest Radiol. 1993 Nov;28(11):1039-42. doi: 10.1097/00004424-199311000-00014.
We preliminarily investigated whether dynamic contrast bolus computed tomography (CT) could be used to measure glomerular filtration rate.
After bolus intravenous contrast injection, rapid sequence CT scans were performed at a fixed level through the kidneys and aorta in three patients with biochemically normal renal function who underwent routine CT examination. A mathematical technique developed initially for positron-emission tomography was adapted for analysis of the CT data for measurement of renal contrast clearance per unit renal volume and of the fraction of renal tissue occupied by blood volume.
Renal blood volumes in the 3 patients were 0.28, 0.29, and 0.31 of total renal volume, respectively, and the corresponding contrast clearances were 0.44, 0.41, and 0.35 mL per min per mL of renal tissue.
This preliminary study in normal patients demonstrates that dynamic contrast CT might be developed for clinical physiological renal studies. Further work to validate the accuracy and reliability of the method in comparison with established isotope methods is suggested.
我们初步研究了动态对比剂团注计算机断层扫描（CT）是否可用于测量肾小球滤过率。
对3例肾功能生化指标正常且接受常规CT检查的患者，静脉注射对比剂团注后，在固定层面通过肾脏和主动脉进行快速序列CT扫描。最初为正电子发射断层扫描开发的一种数学技术被用于分析CT数据，以测量单位肾体积的肾对比剂清除率和血容量占肾组织的比例。
3例患者的肾血容量分别占总肾体积的0.28、0.29和0.31，相应的对比剂清除率分别为每毫升肾组织每分钟0.44、0.41和0.35毫升。
这项对正常患者的初步研究表明，动态对比CT可能会被开发用于临床生理性肾脏研究。建议进一步开展工作，以验证该方法与既定同位素方法相比的准确性和可靠性。
