Lin C K, Hsu H C, Chau W K, Jiang M L, Chiu C F
Department of Internal Medicine, National Yang-Ming Medical College, Taipei, Taiwan, Republic of China.
J Clin Lab Anal. 1993;7(6):371-5. doi: 10.1002/jcla.1860070612.
Using a fully automated reticulocyte counter, the roles of the reticulocyte count with maturation in pancytopenia were evaluated. Different groups of pancytopenia including aplastic anemia, infiltrative marrow disorder, hypersplenism, and megaloblastic anemia were recruited. All patients had bone marrow examinations for morphological diagnosis and reticulocyte evaluation using an automated counter. The roles of these parameters were then analyzed statistically in the differential evaluation among these conditions. The following subjects were studied: 292 normal subjects, 67 cases of aplastic anemia, 69 cases of marrow infiltration by different malignancies, 35 cases of hypersplenism, and 13 cases of megaloblastic anemia. The results showed that the absolute reticulocyte counts were lowest in the groups of aplastic anemia and megaloblastic anemia and highest in hypersplenism. Both showed significant differences from the infiltrative groups. The maturation fractions were most immature in the group of marrow infiltration and are significantly different from the other groups. It was concluded that the highest absolute reticulocyte count (> 0.09 10(12)/L) obtained in pancytopenic patients suggests it to be a case of hypersplenism. The lowest counts (< 0.03 10(12)/L) with lowest immature fractions (< 10%) suggest the groups of aplastic or megaloblastic anemias. The highest immature fractions (> 30%) with a nearly normal reticulocyte count favor the group of marrow infiltration.
使用全自动网织红细胞计数仪，评估了网织红细胞计数及其成熟度在全血细胞减少症中的作用。招募了不同组别的全血细胞减少症患者，包括再生障碍性贫血、骨髓浸润性疾病、脾功能亢进和巨幼细胞贫血。所有患者均进行了骨髓检查以进行形态学诊断，并使用自动计数仪进行网织红细胞评估。然后对这些参数在这些病症的鉴别评估中的作用进行了统计学分析。研究对象如下：292名正常受试者、67例再生障碍性贫血患者、69例不同恶性肿瘤骨髓浸润患者、35例脾功能亢进患者和13例巨幼细胞贫血患者。结果显示，再生障碍性贫血组和巨幼细胞贫血组的绝对网织红细胞计数最低，脾功能亢进组最高。两者与浸润组均有显著差异。骨髓浸润组的成熟分数最不成熟，与其他组有显著差异。得出的结论是，全血细胞减少症患者中获得的最高绝对网织红细胞计数（>0.09×10¹²/L）提示为脾功能亢进病例。计数最低（<0.03×10¹²/L）且未成熟分数最低（<10%）提示为再生障碍性贫血或巨幼细胞贫血组。未成熟分数最高（>30%）且网织红细胞计数接近正常有利于骨髓浸润组。
