Hirano M, Naruki Y, Urita Y, Nakatani N, Noguchi M, Takano M, Maruyama Y, Otsuka S
First Department of Internal Medicine, School of Medicine, Toho University.
Kaku Igaku. 1993 Nov;30(11):1369-77.
As assessment was made regarding the clinical value of 111In transferrin in scintigraphy on 28 lesions in 26 cases of colorectal cancer. The positive rate of colorectal cancer was high: 21 lesions out of the 28 (75%) were found to be positive. As for the location of cancer, there was a tendency for the positive rate to be high in the ascending and transverse colon. There was no obvious trend regarding Borrmann's classification, histological type, or macroscopic depth of invasion. There was a trend for cases in which the maximum diameter of the tumor was large and depth of invasion was in progress to be positive. Ten cases in which a specimen was resected were all shown to be positive by scintigraphy. Radioactivity in the tumorous regions was 4.41 +/- 2.96 times that of the non-tumorous regions. Moreover, tumorous tissue was strongly stained by the immuno-histological staining with anti-Tf.receptor antibody. From the above findings, it was considered that 111In transferrin is clinically useful in scintigraphy, since it is evident that it accumulates in the tissue of colorectal cancer.
对26例结直肠癌患者的28处病灶进行了铟-111转铁蛋白闪烁扫描术的临床价值评估。结直肠癌的阳性率较高：28处病灶中有21处（75%）呈阳性。就癌症发生部位而言，升结肠和横结肠的阳性率有偏高趋势。在Borrmann分型、组织学类型或大体浸润深度方面无明显趋势。肿瘤最大直径较大且浸润深度较深的病例有呈阳性的趋势。10例切除标本的病例经闪烁扫描术均显示为阳性。肿瘤区域的放射性是非肿瘤区域的4.41±2.96倍。此外，用抗转铁蛋白受体抗体进行免疫组织化学染色时，肿瘤组织被强烈染色。根据上述结果，认为铟-111转铁蛋白在闪烁扫描术中具有临床应用价值，因为显然它在结直肠癌组织中蓄积。
