Hoeffken W
Recent Results Cancer Res. 1976(54):262-70. doi: 10.1007/978-3-642-80997-2_23.
Radiotherapy of bone tumors can now be performed exclusively by megavolt therapy. Giant cell tumors hsould be resected. If the lesion is not completely resectable, surgery should be followed by the administration of a target dose of 3000 rads in 4-6 weeks. Inoperable giant cell tumors are irradiated to a tumor dose of 5000 rads, inoperable giant cell tumors of grade III receive a dose of 8000 rads as do osteosarcomas. Ewing's sarcoma and reticulum cell sarcoma can be totally destroyed by a tumor dose of 6000 rad with sufficient reliability. Combination with chemotherapy may offer a chance of improvement. Osteosarcoma should be resected. If surgery is too late (early distant metastases), a tumor dose of 8000 to 10000 rads would be able to destroy the tumor cells. Histologic control investigations have proved this.
骨肿瘤的放射治疗现在完全可以通过兆伏疗法进行。骨巨细胞瘤应行切除术。如果病变不能完全切除，手术后应在4 - 6周内给予3000拉德的靶剂量。无法手术的骨巨细胞瘤照射至肿瘤剂量5000拉德，Ⅲ级无法手术的骨巨细胞瘤与骨肉瘤一样接受8000拉德的剂量。尤文肉瘤和网状细胞肉瘤给予6000拉德的肿瘤剂量能够足够可靠地完全摧毁。与化疗联合可能提供改善的机会。骨肉瘤应行切除术。如果手术太晚（早期远处转移），8000至10000拉德的肿瘤剂量将能够摧毁肿瘤细胞。组织学对照研究已证实了这一点。
