McGowan K D
Department of Gynecology and Obstetrics, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Obstet Gynecol Clin North Am. 1993 Sep;20(3):599-610.
Preimplantation prenatal diagnosis refers to the application of molecular genetic techniques to the assessment of gametes before conception or to early embryos before implantation. Such techniques could allow couples at significant risk for a variety of known genetic diseases to use assisted reproductive technology in achieving pregnancies that are free of the genetic disorder in question. The techniques, their risks, benefits, limitations, and potential applications are described, and recent experiences with human pregnancies are reviewed.
植入前产前诊断是指在受孕前对配子或植入前早期胚胎应用分子遗传学技术进行评估。这些技术可使有患多种已知遗传病重大风险的夫妇利用辅助生殖技术实现无相关遗传病的妊娠。本文描述了这些技术、其风险、益处、局限性及潜在应用，并回顾了近期人类妊娠的相关经验。
