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Tissue distribution of glycine N-methyltransferase, a major folate-binding protein of liver.

作者信息

Yeo E J, Wagner C

机构信息

Vanderbilt University School of Medicine, Nashville, TN.

出版信息

Proc Natl Acad Sci U S A. 1994 Jan 4;91(1):210-4. doi: 10.1073/pnas.91.1.210.

DOI:10.1073/pnas.91.1.210
PMID:8278367
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC42916/
Abstract

Glycine N-methyltransferase (GNMT; S-adenosyl-L-methionine:glycine N-methyltransferase, EC 2.1.1.20) is a major protein in rat liver that binds 5-methyltetrahydrofolate polyglutamate in vivo. This enzyme is believed to function in the regulation of the availability of S-adenosylmethionine, the primary donor of methyl groups in the body. The distribution of GNMT in a variety of rat tissues was examined immunohistochemically. In liver, GNMT was most abundant in the periportal region, whereas in kidney it was seen primarily in the proximal convoluted tubules. In pancreas, GNMT was abundant, principally in the exocrine tissue. GNMT was present in the striated duct cells of the submaxillary gland. In the jejunum, GNMT was found in the epithelial cells of the villi. Close examination of the liver indicated GNMT in the nucleus; this site was confirmed by purification of the nuclei and measurement of enzyme activity. The location of GNMT in the liver and kidney suggests that this enzyme plays a role in gluconeogenesis, while its presence in the exocrine cells suggests it may also be a factor in secretion.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8490/42916/428be480cafd/pnas01532-0230-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8490/42916/adf246aaca14/pnas01532-0228-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8490/42916/1c51b364ef83/pnas01532-0228-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8490/42916/6c58cb000188/pnas01532-0229-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8490/42916/1525d506d659/pnas01532-0229-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8490/42916/428be480cafd/pnas01532-0230-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8490/42916/adf246aaca14/pnas01532-0228-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8490/42916/1c51b364ef83/pnas01532-0228-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8490/42916/6c58cb000188/pnas01532-0229-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8490/42916/1525d506d659/pnas01532-0229-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8490/42916/428be480cafd/pnas01532-0230-a.jpg

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Science. 1993 Feb 12;259(5097):977-80. doi: 10.1126/science.8438158.
2
Protein prenylcysteine analog inhibits agonist-receptor-mediated signal transduction in human platelets.蛋白质异戊烯基半胱氨酸类似物抑制人血小板中激动剂-受体介导的信号转导。
Proc Natl Acad Sci U S A. 1993 Feb 1;90(3):868-72. doi: 10.1073/pnas.90.3.868.
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Purification and characterization of a folate binding protein from rat liver cytosol.
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Commun Biol. 2024 Feb 12;7(1):173. doi: 10.1038/s42003-024-05861-y.
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Sarcosine dehydrogenase as an immune infiltration-associated biomarker for the prognosis of hepatocellular carcinoma.肌氨酸脱氢酶作为肝细胞癌预后的免疫浸润相关生物标志物
J Cancer. 2024 Jan 1;15(1):149-165. doi: 10.7150/jca.89616. eCollection 2024.
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J Biol Chem. 1981 Apr 25;256(8):4102-8.
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Labile methyl group balances in the human: the role of sarcosine.
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Molecular cloning of cDNA for rat glycine methyltransferase.
Biochem Biophys Res Commun. 1984 Oct 15;124(1):44-50. doi: 10.1016/0006-291x(84)90913-6.