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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Schwarzkopf S B, Bruno J P, Mitra T

Department of Psychology, University of Rochester, N.Y.

Prog Neuropsychopharmacol Biol Psychiatry. 1993 Nov;17(6):1023-36. doi: 10.1016/0278-5846(93)90028-q.

Adult Sprague-Dawley rats underwent startle testing for assessment of baseline startle amplitude and prepulse inhibition (PPI) of the startle reflex. 2. Animals were tested after administration of either: saline, a selective D1 dopamine (DA) receptor antagonist, a relatively selective D2 DA antagonist, or combined low dose D1 and D2 antagonists. 3. Changes due to antagonists were assessed with and without administration of the D1/D2 agonist apomorphine. 4. Testing without apomorphine stimulation showed that both D1 and D2 antagonists reduce baseline startle and enhance PPI. Further, the two antagonists exhibited a synergistic interaction. 5. Testing with apomorphine showed that D1 and D2 antagonists reduce apomorphine-induced startle enhancement. Again, the two exhibited a synergistic interaction. 6. For PPI, the D2 but not D1 antagonist reduced the apomorphine effect. However, the D1 antagonist potentiated the effect of the D2 antagonist.

成年斯普拉格-道利大鼠接受惊吓测试，以评估惊吓反射的基线惊吓幅度和前脉冲抑制（PPI）。2. 动物在给予以下物质后进行测试：生理盐水、一种选择性D1多巴胺（DA）受体拮抗剂、一种相对选择性的D2 DA拮抗剂或低剂量D1和D2拮抗剂组合。3. 在给予和不给予D1/D2激动剂阿扑吗啡的情况下评估拮抗剂引起的变化。4. 无阿扑吗啡刺激的测试表明，D1和D2拮抗剂均降低基线惊吓并增强PPI。此外，两种拮抗剂表现出协同相互作用。5. 用阿扑吗啡进行的测试表明，D1和D2拮抗剂降低阿扑吗啡诱导的惊吓增强。同样，两者表现出协同相互作用。6. 对于PPI，D2拮抗剂而非D1拮抗剂降低了阿扑吗啡的作用。然而，D1拮抗剂增强了D2拮抗剂的作用。

Schwarzkopf S B, Bruno J P, Mitra T

Department of Psychology, University of Rochester, N.Y.

Prog Neuropsychopharmacol Biol Psychiatry. 1993 Nov;17(6):1023-36. doi: 10.1016/0278-5846(93)90028-q.

Adult Sprague-Dawley rats underwent startle testing for assessment of baseline startle amplitude and prepulse inhibition (PPI) of the startle reflex. 2. Animals were tested after administration of either: saline, a selective D1 dopamine (DA) receptor antagonist, a relatively selective D2 DA antagonist, or combined low dose D1 and D2 antagonists. 3. Changes due to antagonists were assessed with and without administration of the D1/D2 agonist apomorphine. 4. Testing without apomorphine stimulation showed that both D1 and D2 antagonists reduce baseline startle and enhance PPI. Further, the two antagonists exhibited a synergistic interaction. 5. Testing with apomorphine showed that D1 and D2 antagonists reduce apomorphine-induced startle enhancement. Again, the two exhibited a synergistic interaction. 6. For PPI, the D2 but not D1 antagonist reduced the apomorphine effect. However, the D1 antagonist potentiated the effect of the D2 antagonist.

成年斯普拉格-道利大鼠接受惊吓测试，以评估惊吓反射的基线惊吓幅度和前脉冲抑制（PPI）。2. 动物在给予以下物质后进行测试：生理盐水、一种选择性D1多巴胺（DA）受体拮抗剂、一种相对选择性的D2 DA拮抗剂或低剂量D1和D2拮抗剂组合。3. 在给予和不给予D1/D2激动剂阿扑吗啡的情况下评估拮抗剂引起的变化。4. 无阿扑吗啡刺激的测试表明，D1和D2拮抗剂均降低基线惊吓并增强PPI。此外，两种拮抗剂表现出协同相互作用。5. 用阿扑吗啡进行的测试表明，D1和D2拮抗剂降低阿扑吗啡诱导的惊吓增强。同样，两者表现出协同相互作用。6. 对于PPI，D2拮抗剂而非D1拮抗剂降低了阿扑吗啡的作用。然而，D1拮抗剂增强了D2拮抗剂的作用。