Török I, Stehlich G
Department of Dermatology and Venerology, Semmelweis University of Medicine, Budapest.
Ther Hung. 1993;41(2):60-3.
Comparative examinations were performed with ketoconazole (Nizoral) 1% cream and clotrimazole (Canesten) 2% ointment in 41 patients suffering from superficial dermatomycosis. Twenty-one patients were treated with ketoconazole, twenty patients, with clotrimazole twice daily, for a maximum 4 weeks. The results of the clinical and mycological examinations showed no significant differences when comparing the two groups treated with the different products. Trichophyton rubrum was the most frequently isolated strain in both groups. Side-effect occurred in two of the patients treated with ketoconazole cream (erythema, burning sensation) which did not require the discontinuation of therapy. In the clotrimazole-treated group the therapy had to be discontinued in 3 patients because of dryness of skin, burning sensation, and aggravation of inflammatory symptoms.
对41例浅表皮肤真菌病患者使用1%酮康唑（采乐）乳膏和2%克霉唑（凯妮汀）软膏进行了对比试验。21例患者接受酮康唑治疗，20例患者接受克霉唑治疗，均为每日两次，最长治疗4周。临床和真菌学检查结果显示，比较使用不同产品治疗的两组时，无显著差异。红色毛癣菌是两组中最常分离出的菌株。使用酮康唑乳膏治疗的患者中有2例出现副作用（红斑、烧灼感），但无需停药。在克霉唑治疗组中，有3例患者因皮肤干燥、烧灼感和炎症症状加重而不得不停药。
