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一种新的眼发育迟缓等位基因:早期发育与形态发生性细胞死亡。

A new allele of ocular retardation: early development and morphogenetic cell death.

作者信息

Theiler K, Varnum D S, Nadeau J H, Stevens L C, Cagianut B

出版信息

Anat Embryol (Berl). 1976 Dec 22;150(1):85-97. doi: 10.1007/BF00346288.

DOI:10.1007/BF00346288
PMID:827941
Abstract

The inheritance and some developmental effects of a new allele of ocular retardation (orJ) are described. Affected animals or 12 days of gestation, show reduced cell death in the eye cup and thickening of the inner wall of the optic fissure. At 11 to 13 dyas of gestation orJ/orJ eyes grafted to the testis do not produce retina as their orJ+ littermates do. Adult animals have small eyes with closed lids, abnormal retinal layers, and no optic nerve.

摘要

描述了一种新的眼发育迟缓等位基因(orJ)的遗传及一些发育效应。受影响的动物在妊娠12天时,眼杯中的细胞死亡减少,视神经裂内壁增厚。在妊娠11至13天时,移植到睾丸的orJ/orJ眼睛不像其orJ+同窝仔那样产生视网膜。成年动物眼睛小,眼睑闭合,视网膜层异常,且没有视神经。

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