Wei X, Sulik K K
University of North Carolina Birth Defects Center, Chapel Hill 27599-7090.
Am J Med Genet. 1993 Nov 1;47(6):862-71. doi: 10.1002/ajmg.1320470613.
Ochratoxin A (OA), a mycotoxin commonly found in soils and on moldy food such as cereal grains, is a potent teratogen. The present investigation was designed to examine the teratogenicity of OA administered acutely at early post-implantation stages in mice, with particular emphasis on the pathogenetic basis of induced malformations. Maternal OA administration on gestational day (GD) 7 or 8 resulted in excessive amounts of cell death in selected cell populations. After a single dose of 2-4 mg/kg, excessive cell death was notable within 6 hours, and persisted to 36 hours post-treatment. As observed in GD 14 or 18 fetuses, the spectrum of induced craniofacial malformations included exencephaly, midfacial clefting, cleft lip, as well as hypotelorism, and synophthalmia associated with holoprosencephaly. Body wall defects involved either the abdominal wall alone, or in combination with the thoracic wall, resulting in partial or complete exposure of the viscera. Potential mechanisms for OA-induced selective cell killing are discussed.
赭曲霉毒素A（OA）是一种常见于土壤和发霉食物（如谷物）中的霉菌毒素，是一种强效致畸剂。本研究旨在检测在小鼠植入后早期急性给予OA的致畸性，特别关注诱导畸形的发病机制。在妊娠第7天或第8天给母体施用OA会导致选定细胞群体中大量细胞死亡。单次给予2 - 4mg/kg剂量后，6小时内即可观察到大量细胞死亡，并持续至治疗后36小时。在妊娠第14天或第18天的胎儿中观察到，诱导的颅面畸形包括无脑儿、面中部裂、唇裂，以及与全前脑畸形相关的眼距过窄和独眼畸形。体壁缺陷单独累及腹壁，或与胸壁一起累及，导致内脏部分或完全暴露。文中讨论了OA诱导选择性细胞杀伤的潜在机制。
