Cersosimo E, Coppack S, Jensen M
Endocrine Research Unit, Mayo Clinic, Rochester, Minnesota 55905.
Am J Physiol. 1993 Dec;265(6 Pt 1):E821-4. doi: 10.1152/ajpendo.1993.265.6.E821.
To examine whether hyperglycemia is an independent regulator of adipose tissue lipolysis, we measured palmitate flux ([3H]palmitate) on two occasions in eight volunteers with insulin-dependent diabetes. On one. occasion, euglycemia was maintained for 4 h continuously; on a different occasion, hyperglycemia (plasma glucose, 12 mmol/l) was induced after 2 h of euglycemia. Palmitate flux decreased from 1.39 +/- 0.22 to 1.25 +/- 0.18 mumol.kg-1 x min-1 during sustained euglycemia and from 1.43 +/- 0.24 to 1.13 +/- 0.19 mumol.kg-1 x min-1 during the transition from the euglycemic to the hyperglycemic study intervals. There were no significant differences between the changes in palmitate flux from the first to the second study interval on the control (euglycemia-euglycemia) and experimental (euglycemia-hyperglycemia) study days and no difference between palmitate flux on different study days. Thus, in the face of euinsulinemia, euglucagonemia, and the absence of somatostatin, no effect of hyperglycemia on free fatty acid metabolism could be detected in humans.
为了研究高血糖是否是脂肪组织脂肪分解的独立调节因子，我们在8名胰岛素依赖型糖尿病志愿者身上进行了两次棕榈酸通量（[3H]棕榈酸）的测量。一次，持续维持正常血糖4小时；另一次，在正常血糖2小时后诱导高血糖（血浆葡萄糖，12 mmol/l）。在持续正常血糖期间，棕榈酸通量从1.39±0.22降至1.25±0.18 μmol·kg-1×min-1，在从正常血糖研究期过渡到高血糖研究期时，从1.43±0.24降至1.13±0.19 μmol·kg-1×min-1。在对照（正常血糖-正常血糖）和实验（正常血糖-高血糖）研究日，从第一个研究期到第二个研究期棕榈酸通量的变化之间没有显著差异，不同研究日的棕榈酸通量也没有差异。因此，在存在正常胰岛素血症、正常胰高血糖素血症且无生长抑素的情况下，在人类中未检测到高血糖对游离脂肪酸代谢的影响。
