Tsuji K, Uehara A, Santos S B, Namiki M
Department of Internal Medicine (III), Asahikawa Medical College, Hokkaido, Japan.
Biochem Biophys Res Commun. 1993 Dec 30;197(3):1326-33. doi: 10.1006/bbrc.1993.2622.
It is well-documented that large amounts of endotoxin produce hemorrhagic mucosal lesions in the stomach. To determine whether endotoxin, when injected at small doses, similarly exerts ulcerogenic actions, endotoxin (0.4-40 micrograms/kg) was injected into 24 hr-fasted rats. These small doses of endotoxin did not affect the integrity of the gastric mucosa. Unexpectedly, however, pretreatment with these minute amounts of endotoxin protected the gastric mucosa against various ulcerogenic stimuli such as stress, nonsteroidal anti-inflammatory drugs and ethanol. The anti-ulcer actions of endotoxin were not observed in endotoxin-insensitive animals (C3H/HeJ mice), thereby suggesting that endogenous cytokines such as interleukin-1 may mediate these protective actions. These findings stand in contrast to the toxic effect of endotoxin as an ulcerogen and indicate that endotoxin, albeit its term "toxin," may have a beneficial effect for the host.
大量内毒素会在胃中产生出血性黏膜损伤，这一点已有充分的文献记载。为了确定小剂量注射内毒素是否同样会产生致溃疡作用，将内毒素（0.4 - 40微克/千克）注射到禁食24小时的大鼠体内。这些小剂量的内毒素并未影响胃黏膜的完整性。然而，出乎意料的是，用这些微量内毒素进行预处理可保护胃黏膜免受各种致溃疡刺激，如应激、非甾体抗炎药和乙醇。在内毒素不敏感的动物（C3H/HeJ小鼠）中未观察到内毒素的抗溃疡作用，从而表明白细胞介素 - 1等内源性细胞因子可能介导了这些保护作用。这些发现与内毒素作为致溃疡原的毒性作用形成对比，并表明内毒素尽管有“毒素”之名，但可能对宿主有有益作用。
