Tariq M
Department of Pharmacology and Research Center, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
Res Commun Chem Pathol Pharmacol. 1988 Apr;60(1):87-96.
Effect of vitamin E on the gastric mucosal damage induced by hypothermic restraint stress, indomethacin, reserpine, hydrochloric acid, sodium chloride and ethanol has been studied in rats. The results demonstrate that pretreatment of animals with vitamin E produces a significant inhibition of gastric lesions induced by above mentioned agents. An increase in the synthesis of prostaglandins, and high level of glutathione in tissues of vitamin E treated animals have been suggested as a possible mechanism of anti-ulcer activity of -tocopherol. However, further studies are required to confirm these effects and to determine the role of vitamin E in the prophylaxis and treatment of peptic ulcer disease.
已经在大鼠中研究了维生素E对由低温束缚应激、消炎痛、利血平、盐酸、氯化钠和乙醇诱导的胃粘膜损伤的影响。结果表明，用维生素E预处理动物可显著抑制上述药物诱导的胃损伤。有人提出，维生素E处理的动物组织中前列腺素合成增加以及谷胱甘肽水平升高可能是α-生育酚抗溃疡活性的机制。然而，需要进一步研究来证实这些作用，并确定维生素E在消化性溃疡疾病的预防和治疗中的作用。
