Kadoya C, Matsuoka S, Domino E F
Department of Pharmacology, University of Michigan, Ann Arbor 48109-0626.
Neuropsychopharmacology. 1993 Nov;9(3):233-8. doi: 10.1038/npp.1993.59.
Ten normal adult tobacco smoking volunteers 21 to 32 years of age were the subjects of this study. They were asked not to smoke for 12 hours prior to testing. The Hoffmann (H) reflex and its recovery cycle were measured before and just after smoking (on different days) one nonfiltered, zero, low (0.27 mg), or high (2.16 mg) nicotine tobacco cigarette. After smoking the nicotine-containing cigarettes, the subjects showed a reduction of the H reflex recovery cycle. Individual differences were marked. Nevertheless, the data obtained are consistent with evidence in animals that nicotine and tobacco smoke stimulate Renshaw inhibitory neurons in the spinal cord, either directly or indirectly. This technique provides another objective measure of the effects of tobacco smoking in human volunteers.
10名年龄在21至32岁之间的正常成年吸烟志愿者参与了本研究。要求他们在测试前12小时内不得吸烟。在吸食一支无过滤嘴、零尼古丁、低尼古丁（0.27毫克）或高尼古丁（2.16毫克）香烟之前和刚吸食后（在不同日期）测量霍夫曼（H）反射及其恢复周期。吸食含尼古丁香烟后，受试者的H反射恢复周期缩短。个体差异明显。然而，所获得的数据与动物实验证据一致，即尼古丁和烟草烟雾直接或间接刺激脊髓中的闰绍抑制性神经元。该技术为吸烟对人类志愿者的影响提供了另一种客观测量方法。
