Martínez A J, Pascual M, Larralde J
Department of Physiology and Nutrition, University of Navarra, Pamplona, Spain.
Biochim Biophys Acta. 1994 Jan 5;1199(1):101-3. doi: 10.1016/0304-4165(94)90103-1.
The acute systemic effects of IGF-I on bone protein metabolism from hormonally intact rats have been investigated by measuring the fractional rate of protein synthesis. The animals received a single subcutaneous injection of rhIGF-I (100 micrograms). Treatment with IGF-I increased the rate of tibia protein synthesis (Ks) while plasma glucose and insulin concentrations were decreased. These results are in favor of an endocrine role of IGF in stimulating bone growth.
通过测量蛋白质合成的分数率，研究了胰岛素样生长因子-I（IGF-I）对激素功能正常大鼠骨蛋白代谢的急性全身影响。给动物皮下单次注射重组人胰岛素样生长因子-I（100微克）。IGF-I治疗增加了胫骨蛋白质合成率（Ks），同时血浆葡萄糖和胰岛素浓度降低。这些结果支持IGF在刺激骨骼生长中起内分泌作用。
