Pereira Lage A, Glupczynski Y, Goossens H, Burette A, Butzler J P
WHO Collaborating Center for Enteric Campylobacter, St. Pieter's University Hospital, Brussels, Belgium.
Zentralbl Bakteriol. 1993 Sep;280(1-2):197-202. doi: 10.1016/s0934-8840(11)80956-4.
Sera from 36 patients with gastritis only and 26 patients with peptic ulcer were tested for the presence of neutralising antibodies against H. pylori vacuolating toxin. The frequency with which sera did neutralise the vacuolating toxin was not significantly different among the groups of patients with gastroduodenal ulcer infected either with toxigenic or nontoxigenic H. pylori strains (9/14 vs 4/12; ns) or in patients with gastritis only harbouring toxigenic H. pylori strains (8/12). By contrast, none of 24 sera obtained from patients with gastritis and harbouring non-toxigenic H. pylori strains did neutralise the vacuolating toxin. It is suggested that H. pylori vacuolating toxin is involved in the pathogenesis of peptic ulcer disease.
对36例仅患有胃炎的患者和26例患有消化性溃疡的患者的血清进行检测，以确定是否存在针对幽门螺杆菌空泡毒素的中和抗体。在感染产毒或不产毒幽门螺杆菌菌株的胃十二指肠溃疡患者组中（9/14对4/12；无显著性差异），或仅患有胃炎且携带产毒幽门螺杆菌菌株的患者中（8/12），血清中和空泡毒素的频率无显著差异。相比之下，从患有胃炎且携带不产毒幽门螺杆菌菌株的患者中获得的24份血清均未中和空泡毒素。这表明幽门螺杆菌空泡毒素参与了消化性溃疡疾病的发病机制。
