Fischer K, Poschmann A
Immun Infekt. 1976 Dec;4(6):249-60.
Haemolytic disease of the newborn is mostly caused by Rh antibody anti-D (Rh erythroblastosis) and antibodies of the ABO system anti-A and anti-B (ABO erythroblastosis). Because of possible fetal death in utero prenatal diagnosis and treatment of Rh erythroblastosis is necessary. Prophylactic administration of anti-Rh-gammaglobulin prevents the induction of Rh antibodies. In contrast to Rh erythroblastosis prenatal diagnosis and treatment of ABO erythroblastosis is not necessary. Postnatally, however, hyperbilirubinemia due to ABO erythroblastosis should be treated to avoid Kernicterus. Our results with diagnosis and treatment of haemolytic diseases of the newborn are presented and related to the literature. Furthermore, immunofluorescence studies are reported, which could possibly explain the differences between Rh and ABO erythroblastosis.
新生儿溶血病大多由抗-D Rh抗体（Rh溶血病）以及ABO系统的抗-A和抗-B抗体（ABO溶血病）引起。由于Rh溶血病可能导致胎儿宫内死亡，因此有必要对其进行产前诊断和治疗。预防性注射抗Rh丙种球蛋白可防止Rh抗体的产生。与Rh溶血病不同，ABO溶血病无需进行产前诊断和治疗。然而，出生后，ABO溶血病所致的高胆红素血症应予以治疗以避免核黄疸。本文展示了我们对新生儿溶血病的诊断和治疗结果，并与相关文献进行了比较。此外，还报告了免疫荧光研究，这可能解释Rh溶血病和ABO溶血病之间的差异。
