Büttemeyer R, Jones N F, Vogt P, Steinau H U
Division of Plastic and Reconstructive Surgery, University of California, Los Angeles.
Chirurg. 1993 Nov;64(11):907-12.
The experimental and clinical progress in the field of immunosuppression, microsurgical replantation and macro-replantation provides a basis for the allotransplantation of whole limbs or anatomical segments. Possible indications would be clinically: Posttraumatic and tumor-induced defects, as well as congenital and infectious mutilations. Specific immunological problems of rejection under different immunosuppressive regimens and future methods for the induction of immune tolerance are discussed.
免疫抑制、显微外科再植和大肢体再植领域的实验与临床进展为全肢体或解剖节段的同种异体移植提供了基础。临床上可能的适应症包括:创伤后和肿瘤引起的缺损,以及先天性和感染性肢体残缺。文中讨论了不同免疫抑制方案下排斥反应的具体免疫学问题以及诱导免疫耐受的未来方法。