Daniel F B, Robinson M, Olson G R, York R G, Condie L W
Ecological Monitoring Research Division, U.S. Environmental Protection Agency, Cincinnati, Ohio 45268.
Drug Chem Toxicol. 1993;16(4):351-68. doi: 10.3109/01480549308998226.
Male and female Sprague-Dawley rats received 2,4-dimethylphenol daily by gavage for 10 or 90 consecutive days. The 10-day acute study doses were 0, 60, 120, 600 and 1200 mg/kg; the 90-day subchronic study doses were 0, 60, 180 and 540 mg/kg. Corn oil was used as the vehicle. In the 10-day study, all the high dose animals died. At 600 mg/kg there was a significant increase in relative liver weight in females and several significant alterations in hematologic and clinical chemistry values in both sexes. Histopathological examination revealed changes associated with the forestomach in all dose groups. The 90-day study had numerous compound-related deaths at the 540 mg/kg level. In addition, the final body weight in high dose males and females was significantly less while absolute lung weights and relative liver weights in females, and relative brain, kidney and testes weights in males were also altered. Significant clinical chemistry findings in high dose animals (540 mg/kg) included reduced creatinine and increased cholesterol in both sexes, with increased triglycerides and decreased AST in males only. Histopathologic evaluation revealed hyperkeratosis and epithelial hyperplasia of the forestomach in males and females in the middle and high-dose groups.
将雄性和雌性斯普拉格-道利大鼠每日经口灌胃给予2,4-二甲基苯酚，连续给药10天或90天。10天急性研究的剂量分别为0、60、120、600和1200毫克/千克；90天亚慢性研究的剂量分别为0、60、180和540毫克/千克。玉米油用作赋形剂。在10天的研究中，所有高剂量组动物均死亡。在600毫克/千克剂量组，雌性动物的相对肝脏重量显著增加，两性的血液学和临床化学值均出现若干显著变化。组织病理学检查显示，所有剂量组均出现与前胃相关的变化。在90天的研究中，540毫克/千克剂量组出现大量与化合物相关的死亡。此外，高剂量组雄性和雌性动物的最终体重显著降低，雌性动物的绝对肺重量和相对肝脏重量以及雄性动物的相对脑、肾和睾丸重量也发生了改变。高剂量组动物（540毫克/千克）的显著临床化学结果包括两性的肌酐降低和胆固醇升高，仅雄性动物的甘油三酯升高和天冬氨酸转氨酶降低。组织病理学评估显示，中高剂量组雄性和雌性动物的前胃均出现角化过度和上皮增生。
