Ohno N, Ito K M, Yamamoto Y, Suzuki H
Department of Physiology, Nagoya City University Medical School, Japan.
Eur J Pharmacol. 1993 Nov 2;249(1):121-3. doi: 10.1016/0014-2999(93)90671-4.
In smooth muscle cells of the guinea-pig stomach fundus, transmural nerve stimulation evoked a cholinergic excitatory junction potential (e.j.p.) and, in the presence of atropine, a non-adrenergic non-cholinergic (NANC) inhibitory junction potential (i.j.p.). Suramin (> 10(-5) M), a putative inhibitor of the P2 purinoceptor, enhanced the e.j.p. amplitude and inhibited the i.j.p., with no significant effect on the membrane potential. Thus, a possible involvement of ATP in the generation of the NANC i.j.p. has to be considered.
