Fukui H, Yamamoto M, Sasaki S, Sato S
Drug Safety Research Laboratories, Takeda Chemical Industries, Ltd., Osaka, Japan.
Eur J Pharmacol. 1993 Nov 2;249(1):13-8. doi: 10.1016/0014-2999(93)90656-3.
The emetic effects of copper sulfate and cisplatin and the potential involvement of vagal afferent fibers and 5-HT3 receptors in the emesis were investigated in cynomolgus monkeys. Retching and vomiting induced by both oral (100 mg/kg) and intravenous (20 mg/kg) copper sulfate were inhibited markedly by abdominal vagotomy. Furthermore, the emetic response induced by oral copper sulfate was strongly inhibited by intravenous ICS 205-930 (0.1 mg/kg), a 5-HT3 receptor antagonist. Cisplatin (3 mg/kg, i.v.) caused severe retching and vomiting, and the number of emetic responses was much greater than that in other species. The emetic response induced by cisplatin was inhibited markedly by abdominal vagotomy or concurrent administration of ICS 205-930 (3 x 0.1 mg/kg, i.v.). These results suggest that the monkey is more sensitive to cisplatin than other species and that the vagal afferent terminals and 5-HT3 receptors play an important role in the emetic response induced by copper sulfate and cisplatin.
在食蟹猴中研究了硫酸铜和顺铂的催吐作用以及迷走传入纤维和5-HT3受体在呕吐中的潜在作用。口服（100mg/kg）和静脉注射（20mg/kg）硫酸铜引起的干呕和呕吐均被腹部迷走神经切断术显著抑制。此外，静脉注射5-HT3受体拮抗剂ICS 205-930（0.1mg/kg）可强烈抑制口服硫酸铜引起的催吐反应。顺铂（3mg/kg，静脉注射）引起严重的干呕和呕吐，催吐反应的次数远多于其他物种。腹部迷走神经切断术或同时给予ICS 205-930（3×0.1mg/kg，静脉注射）可显著抑制顺铂引起的催吐反应。这些结果表明，猴子对顺铂比其他物种更敏感，并且迷走传入终末和5-HT3受体在硫酸铜和顺铂引起的催吐反应中起重要作用。
