Kholodenko B N, Cascante M, Westerhoff H V
Department de Bioquimica i Fisiologia, Universitat de Barcelona, Spain.
FEBS Lett. 1993 Dec 28;336(3):381-4. doi: 10.1016/0014-5793(93)80841-h.
A simple summation theorem describes the control of fluxes in 'ideal' metabolic pathways. This paper shows how this theorem and the control properties of a pathway change when direct transfer of intermediates and/or sequestration of metabolites involved in moiety conservations (by enzymes present at high concentrations) take place. The derived generalized summation theorem quantifies the extent to which metabolite sequestration decreases and direct metabolite transfer can increase the control exerted by enzymes on the flux. The implications of metabolite channelling for the control of fluxes are discussed quantitatively.
一个简单的求和定理描述了“理想”代谢途径中的通量控制。本文展示了该定理以及当中间产物直接转移和/或参与部分守恒的代谢物（由高浓度存在的酶）被隔离时途径的控制特性如何变化。推导得出的广义求和定理量化了代谢物隔离降低以及代谢物直接转移可增加酶对通量施加控制的程度。定量讨论了代谢物通道化对通量控制的影响。
