Vessey M P, Goldacre M J, Seagroatt V, Yeates D
Department of Public Health & Primary Care, Radcliffe Infirmary, Oxford.
Gut. 1993 Dec;34(12):1660-1. doi: 10.1136/gut.34.12.1660.
A previous cohort study suggested that there might be an association between use of cimetidine and motor neurone disease. The Oxford Record Linkage Study was used to explore this hypothesis. In the analysis the presence of a peptic ulcer in patients after 1976 was taken as a proxy for cimetidine (and ranitidine) use. The past history of 540 patients with motor neurone disease in this period was compared with that of 1370 patients with multiple sclerosis (neurological controls) and over 240,000 control patients with a variety of other conditions. Among those with motor neurone disease, five had been previously admitted to hospital with peptic ulcer in comparison with an expected number of 7.4 (morbidity ratio 0.68, 95% confidence interval: 0.2 to 1.6). The corresponding figures for those with multiple sclerosis were 12 and 9.7 respectively (morbidity ratio 1.24, 95% confidence interval: 0.6 to 2.2). This study provides some evidence against the possibility that cimetidine (and ranitidine) are related to motor neurone disease.
之前的一项队列研究表明，西咪替丁的使用与运动神经元病之间可能存在关联。牛津记录链接研究被用于探究这一假设。在分析中，1976年之后患者是否存在消化性溃疡被用作使用西咪替丁（和雷尼替丁）的替代指标。将这一时期540例运动神经元病患者的既往病史与1370例多发性硬化症患者（神经学对照）以及超过240,000例患有各种其他疾病的对照患者的既往病史进行了比较。在运动神经元病患者中，有5例曾因消化性溃疡入院，而预期数字为7.4（发病率比0.68，95%置信区间：0.2至1.6）。多发性硬化症患者的相应数字分别为12和9.7（发病率比1.24，95%置信区间：0.6至2.2）。这项研究提供了一些证据，反驳了西咪替丁（和雷尼替丁）与运动神经元病有关的可能性。
