Young M D, Baerg D C, Rossan R N
Lab Anim Sci. 1976 Dec;26(6 Pt 2):1131-7.
Aotus monkeys have been shown to be susceptible to the three most important species of human malaria as well as to simian, ape, and rodent malaria. The parasites natural to man were maintained by serial passages using trophozoite infected blood. It was then possible to transfer the infections to, and among, other New World monkeys which previously were refractory. The parasites retained their viability in the monkey, were infective to mosquitos, and were transmitted between monkeys and back to man. Exoerythrocytic stages, similar to those demonstrated in man, occurred in the Aotus liver. Drugs exerted similar action against the parasites in the monkey as against parasites in man. The human malaria-Aotus model has made possible other extensive studies in various disciplines important to the understanding of the parasites in man. These included parasite biology, host-parasite-vector relationships, immunology, pathology, and physiology.
夜猴已被证明对人类三种最重要的疟原虫以及猿猴、猿和啮齿动物疟原虫敏感。通过使用滋养体感染的血液进行连续传代来维持人类天然的寄生虫。然后有可能将感染转移到其他以前难治的新大陆猴身上，并在它们之间传播。这些寄生虫在猴子体内保持其活力，对蚊子具有传染性，并在猴子之间传播并再次传染给人类。在夜猴肝脏中出现了类似于在人类中发现的红细胞外期。药物对猴子体内的寄生虫的作用与对人类体内寄生虫的作用相似。人类疟疾-夜猴模型使得在对理解人类寄生虫至关重要的各个学科中进行其他广泛研究成为可能。这些学科包括寄生虫生物学、宿主-寄生虫-媒介关系、免疫学、病理学和生理学。
