Cabral A M, Carvalhinho F B, Vasquez E C, Cicilini M A
Department of Physiological Sciences, Biomedical Center, UFES, Vitoria, Brazil.
Hypertension. 1994 Jan;23(1 Suppl):I180-4. doi: 10.1161/01.hyp.23.1_suppl.i180.
Diuretics have been the mainstay of long-term treatment of hypertension, but there is no evidence suggesting that diuretics may be effective in reducing cardiac hypertrophy associated with hypertension. Thus, the present study was carried out to elucidate if long-term treatment with chlorthalidone (8 mg per animal per day added to food) affects the development of and reverses the ventricular hypertrophy in deoxycorticosterone acetate (DOCA) (8 mg/kg SC twice a week)-salt hypertensive rats. Chlorthalidone was given to one group during all 20 days of DOCA administration (preventive regimen) and to another group 20 days after DOCA treatment was initiated until the 40th day (therapeutic regimen). Chlorthalidone was found to reduce or prevent the development of ventricular hypertrophy, as assessed by a reduction in ventricular mass and cardiac protein as well as arterial hypertension. Both chlorthalidone regimens prevented the increase or induced a significant decrease in the plasma concentration of sodium and in cardiac sympathetic tone, which were both increased in DOCA-salt-treated rats. These data provide evidence that long-term chlorthalidone treatment is effective in preventing or reducing ventricular hypertrophy along with arterial hypertension. However, whether this is due to a reduction in plasma sodium or other additional mechanisms, such as a reduction in cardiac sympathetic tone, remains to be determined.
利尿剂一直是高血压长期治疗的主要药物，但没有证据表明利尿剂在减轻与高血压相关的心脏肥大方面可能有效。因此，本研究旨在阐明长期用氯噻酮（每天每只动物8毫克添加到食物中）治疗是否会影响醋酸脱氧皮质酮（DOCA）（8毫克/千克皮下注射，每周两次）-盐性高血压大鼠的心室肥大发展并使其逆转。在DOCA给药的全部20天内给一组大鼠服用氯噻酮（预防方案），在DOCA治疗开始20天后给另一组大鼠服用氯噻酮直至第40天（治疗方案）。通过心室质量、心脏蛋白以及动脉高血压的降低来评估，发现氯噻酮可减轻或预防心室肥大的发展。两种氯噻酮方案均能防止血浆钠浓度升高或使其显著降低，并且能防止DOCA-盐处理大鼠心脏交感神经张力升高或使其显著降低。这些数据证明长期氯噻酮治疗在预防或减轻心室肥大以及动脉高血压方面是有效的。然而，这是否是由于血浆钠降低或其他额外机制，如心脏交感神经张力降低，仍有待确定。
