Lin D B, Chen C J
Department of Medical Technology, Chung Shan Medical and Dental College, Taichung, Taiwan.
J Med Virol. 1993 Oct;41(2):174-8. doi: 10.1002/jmv.1890410215.
To examine the epidemiological characteristics of rubella virus infection on Taiwan Island and in Orchid and Pescadore islets, a community-based survey was carried out in 19 townships and metropolitan precincts randomly selected through stratified sampling. Serum specimens of 4,770 healthy girls and women randomly sampled from study areas were screened for the rubella antibody by passive latex agglutination testing and confirmed by enzyme-linked immunosorbent assay. A total of 2,934 subjects were antibody positive, giving a prevalence of 61.5%. The mean +/- standard deviation of rubella IgG index was 2.51 +/- 0.37. The seropositive rate increased with age in all residential areas and ethnic groups. The age pattern indicated that the regular 10-year cycle of rubella epidemic was no longer existent after 1978. A higher prevalence was observed in the eastern island and Orchid Islets compared with other areas. The highest seropositive rate was found in Orchid Islets. The overall seronegative rate was 62.9% for females < 20 years of age and 36.9% for women between the ages of 20 and 29 years. With such a high susceptible density among girls and women of child-bearing ages as well as the endemicity of rubella virus infection in Taiwan, mass vaccination against rubella should be enforced in order to prevent possible future outbreaks of the congenital rubella syndrome.
为了研究台湾岛及兰屿、绿岛风疹病毒感染的流行病学特征，通过分层抽样在随机选取的19个乡镇和市区开展了一项基于社区的调查。从研究区域随机抽取4770名健康女童和成年女性的血清样本，采用被动乳胶凝集试验筛查风疹抗体，并通过酶联免疫吸附测定进行确认。共有2934名受试者抗体呈阳性，患病率为61.5%。风疹IgG指数的平均值±标准差为2.51±0.37。在所有居住区和族群中，血清阳性率均随年龄增长而升高。年龄模式表明，1978年后风疹流行的常规10年周期已不复存在。与其他地区相比，东部岛屿和兰屿的患病率较高。兰屿的血清阳性率最高。20岁以下女性的总体血清阴性率为62.9%，20至29岁女性为36.9%。鉴于台湾育龄期女童和成年女性的易感密度如此之高，以及风疹病毒感染的地方性流行情况，应实施风疹大规模疫苗接种，以预防未来可能出现的先天性风疹综合征疫情。
