Hafiz S, Khan S W, Shariff R, Yazdani I, Syed Y, Hafiz T
Zafar Research and Diagnostic Centre, Karachi.
J Pak Med Assoc. 1993 Sep;43(9):178-9.
Over the past five years 25,000 blood cultures were screened for septicaemia. Of these 6.7% were positive for salmonella species, the commonest being salmonella typhi accounting for 92% of total salmonella isolates. Over the years, S. typhi showed a gradual decline ranging from 96.7 to 87%. While salmonella paratyphi A has shown a gradual increase ranging from 2.5% to 11.4%. Salmonellosis peaked in the year 1990 suggesting an epidemic. The antibiotic sensitivity pattern showed a gradual increase in resistance over the years and even resistance to the new quinolones has emerged. Thus salmonellosis poses a major threat to the community and we must look into the alternative antibiotics to combat the threat.
在过去五年中，对25000份血培养样本进行了败血症筛查。其中6.7%的样本沙门氏菌属呈阳性，最常见的是伤寒沙门氏菌，占沙门氏菌分离株总数的92%。多年来，伤寒沙门氏菌呈逐渐下降趋势，从96.7%降至87%。而甲型副伤寒沙门氏菌呈逐渐上升趋势，从2.5%升至11.4%。沙门氏菌病在1990年达到高峰，表明出现了疫情。抗生素敏感性模式显示，多年来耐药性逐渐增加，甚至出现了对新型喹诺酮类药物的耐药性。因此，沙门氏菌病对社区构成了重大威胁，我们必须研究替代抗生素来应对这一威胁。
