Huppertz H I, Gohlke F, Horwitz A E
Kinderklinik, Universität Würzburg.
Monatsschr Kinderheilkd. 1993 Nov;141(11):883-7.
Steroids are among the most potent antirheumatic drugs, but carry unacceptable adverse effects during long-term systemic application. In children with pauciarthritis intra-articular steroids have been recommended.
We assessed the effect of intra-articular triamcinolone-hexacetonide in 16 joints of 12 children and adolescents with chronic arthritis unresponsive to non-steroidal anti-inflammatory agents.
All joints improved and no side effects were observed by clinical and roentgenographic means. After a follow-up of 12 months after a single injection 9 joints were without arthritis and 3 joints showed minimal effusion without limitation of motion. In 4 joints arthritis reappeared after 1, 6, 7 and 7 months.
Intra-articular steroid therapy is a highly effective alternative in the treatment of children and adolescents with chronic arthritis.
类固醇是最有效的抗风湿药物之一，但长期全身应用会产生难以接受的不良反应。对于少关节型关节炎患儿，推荐使用关节内注射类固醇。
我们评估了曲安奈德己酸酯关节内注射对12名慢性关节炎儿童和青少年的16个关节的效果，这些患儿对非甾体抗炎药无反应。
所有关节均有改善，临床和影像学检查均未观察到副作用。单次注射后随访12个月，9个关节无关节炎，3个关节有轻微积液，但活动无受限。4个关节分别在1、6、7和7个月后关节炎复发。
关节内类固醇治疗是治疗儿童和青少年慢性关节炎的一种高效替代方法。
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