Huckabee K D, Barnes R T, Williams A G, Fan W L, Downey H F
Department of Physiology, Texas College of Osteopathic Medicine, Fort Worth.
Oral Surg Oral Med Oral Pathol. 1993 Dec;76(6):729-35. doi: 10.1016/0030-4220(93)90043-4.
Regional blood flow to the cheek and tongue of anesthetized dogs was measured before and after application of six different doses of snuff (3.12 to 100 mg/kg body weight) to the right cheek. Dose-independent vasodilation was observed at the site of application, whereas dose-dependent vasoconstriction was observed contralaterally. Aortic, central venous, and ventricular pressures were significantly increased (p < 0.05) at the higher doses. Plasma nicotine concentrations increased stepwise with dose.
在对麻醉犬右侧脸颊施加六种不同剂量的鼻烟（3.12至100毫克/千克体重）之前和之后，测量了脸颊和舌头的局部血流。在施用部位观察到与剂量无关的血管舒张，而在对侧观察到剂量依赖性血管收缩。在较高剂量下，主动脉、中心静脉和心室压力显著升高（p<0.05）。血浆尼古丁浓度随剂量逐步增加。
