Livraghi T, Paracchi A, Ferrari C, Reschini E, Macchi R M, Bonifacino A
Department of Radiology, Ospedale Civile, Vimercate, Milan, Italy.
Radiology. 1994 Feb;190(2):529-33. doi: 10.1148/radiology.190.2.8284411.
To evaluate the long-term efficacy of treatment of autonomous thyroid nodules with percutaneous ethanol injection under ultrasound guidance.
Treatment was performed in 101 patients. The mean ratio of injected ethanol volume to nodule volume was approximately 1.5; ethanol was usually administered in four to eight sessions.
Complete cure was achieved in 59 patients. Partial cure was achieved in 34 patients. Eight patients had remission of thyrotoxicosis but persistence of thyroid-stimulating hormone level suppression and radionuclide uptake only in the nodule. The extent of the response was inversely proportional to the nodule volume. Marked nodule shrinkage was observed in all groups. No recurrences were observed. Transient vocal cord paresis occurred in four patients, with full recovery in all cases.
This method compares favorably with both surgery and radioiodine treatment, especially when the very low prevalence of posttreatment hypothyroidism is considered.
评估超声引导下经皮乙醇注射治疗自主性甲状腺结节的长期疗效。
对101例患者进行了治疗。注入乙醇体积与结节体积的平均比值约为1.5；乙醇通常分4至8次给药。
59例患者完全治愈。34例患者部分治愈。8例患者甲状腺毒症缓解，但仅结节处存在促甲状腺激素水平抑制和放射性核素摄取。反应程度与结节体积成反比。所有组均观察到明显的结节缩小。未观察到复发。4例患者出现短暂性声带麻痹，所有病例均完全恢复。
该方法与手术和放射性碘治疗相比具有优势，尤其是考虑到治疗后甲状腺功能减退的发生率极低时。
