Ceccon M E, Diniz E M, Ramos J L, Vaz F A
Instituto da Criança Prof. Pedro de Alcantara, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, Brasil.
Rev Paul Med. 1993 Mar-Apr;111(2):348-53.
A study was conducted on 115 full-term newborn infants with fetal-maternal ABO or Rh incompatibility submitted to exchange transfusion (EXT) due to hyperbilirubinemia. Donor blood was preserved in sodium citrate-sodium phosphate-dextrose-adenine (CPDA-1) and stored for a maximum of 48 hours. The volume of blood exchange was equivalent to two blood volumes of the infant and the procedure took approximately two hours. The following results were obtained with respect to bilirubins: 1) EXT let to a 44.03% reduction in indirect bilirubin in the ABO group and to a 43.40% reduction in the Rh group, thus demonstrating the efficacy of this procedure. 2) EXT was indicated earlier and in the presence of lower indirect bilirubin levels in the Rh group, which was also the group which required more frequent repetition of EXT (44.40% as opposed to 17.10% for the Rh group. 3) In both the ABO and Rh groups, the indirect bilirubin value that most closely approached the level for EXT indication was that obtained 3 hours post-EXT (least significant percent difference).
对115例因高胆红素血症接受换血治疗（EXT）的足月新生儿进行了一项研究，这些新生儿存在母婴ABO或Rh血型不合。供血保存在枸橼酸钠-磷酸二氢钠-葡萄糖-腺嘌呤（CPDA-1）中，最多保存48小时。换血的血量相当于婴儿血容量的两倍，该过程耗时约两小时。关于胆红素得到了以下结果：1）在ABO组中，换血使间接胆红素降低了44.03%，在Rh组中降低了43.40%，从而证明了该治疗方法的有效性。2）在Rh组中，换血指征出现得更早，且间接胆红素水平更低，该组也需要更频繁地重复换血（44.40%，而ABO组为17.10%）。3）在ABO组和Rh组中，最接近换血指征水平的间接胆红素值是在换血后3小时测得的（最小显著百分比差异）。
