Hirata T, Fukuse T, Liu C J, Muro K, Yokomise H, Yagi K, Inui K, Hitomi S, Wada H
Department of Thoracic Surgery, Kyoto University, Japan.
Surgery. 1994 Jan;115(1):102-7.
The effect of trehalose on the preservation of canine lungs was studied with the use of Euro-Collins solution (ECS).
In group 1, five lungs were perfused and preserved with a modified ECS in which trehalose (35.0 gm/L) was used instead of glucose. In group 2, six lungs were perfused and preserved with a modified ECS in which glucose was replaced by 70.0 gm/L trehalose. In group 3, six lungs were perfused and preserved with ECS. After preservation for 12 hours, left lung transplantation was performed.
The PaO2 values in groups 1 and 2 at 130 minutes after reperfusion were 264.9 and 257.5 mm Hg, respectively. These PaO2 values were significantly higher than the corresponding PaO2 value in group 3 (114.8 mm Hg). All the transplanted lungs in groups 1 and 2 had normal structures on histologic examination, whereas five of the group 3 lungs showed severe pulmonary edema.
These findings show that trehalose is effective in the preservation of lungs for 12 hours.
使用欧洲柯林斯溶液（ECS）研究海藻糖对犬肺保存的影响。
在第1组中，用一种改良的ECS灌注并保存5个肺，其中用海藻糖（35.0克/升）代替葡萄糖。在第2组中，用一种改良的ECS灌注并保存6个肺，其中葡萄糖被70.0克/升海藻糖取代。在第3组中，用ECS灌注并保存6个肺。保存12小时后，进行左肺移植。
再灌注130分钟时，第1组和第2组的动脉血氧分压（PaO2）值分别为264.9和257.5毫米汞柱。这些PaO2值显著高于第3组相应的PaO2值（114.8毫米汞柱）。组织学检查显示，第1组和第2组所有移植肺结构正常，而第3组有5个肺出现严重肺水肿。
这些发现表明，海藻糖对肺保存12小时有效。
