Volpe M, Tritto C, Condorelli M
Acta Cardiol. 1993;48(5):483-94.
Neurohormonal activation is a fundamental component in the pathophysiology of congestive heart failure. In fact it represents a mechanism consecutive to cardiac dysfunction that favours the development of congestion and of further heart failure through vasoconstriction and water and salt retention. The time of onset and the mechanisms responsible for neurohormonal activation in heart failure are not defined. This brief article reviews this topic and summarizes the findings of studies that investigated the dynamic adaptations of hormonal mechanisms in the milder or initial stages of heart failure. An early characterization and detection of the abnormalities of the hormonal responses to salt or volume changes may be useful for a better comprehension and the treatment of the initial stage of the disease.
神经激素激活是充血性心力衰竭病理生理学的一个基本组成部分。事实上，它代表了一种继发于心脏功能障碍的机制，通过血管收缩以及水和盐潴留，促进充血和进一步心力衰竭的发展。心力衰竭中神经激素激活的起始时间和机制尚未明确。这篇短文回顾了该主题，并总结了研究结果，这些研究调查了心力衰竭较轻或初始阶段激素机制的动态适应性。对盐或容量变化的激素反应异常进行早期特征描述和检测，可能有助于更好地理解和治疗疾病的初始阶段。
