Folk R M, Pavkov K L, Thake D C
Cancer Treat Rep. 1976 Oct;60(10):1585-9.
Thirty dogs in four different treatment schedules and 14 monkeys in a single multiple-treatment schedule were used to evaluate the toxicity of dianhydrogalactitol. Highest nontoxic, low toxic, high toxic, and lethal doses were established in single injection doses and five daily injections in dogs, and in five daily injections in monkeys. Dose ranges of 20-320 mg/m2 (single injection) and 5-80 mg/m2 (five daily injections) in dogs, and 3-96 mg/m2 (five daily injections) in monkeys were established. The monkeys were more sensitive than dogs to the low toxic dose and more tolerant to the high toxic dose in the repeated daily injections. The dose-response curves for the dogs and monkeys had similar slopes and inflection points. Because of the steep slope between the lethal dose and the highest nontoxic dose in both species, caution should be used in the initial clinical trials.
使用30只接受四种不同治疗方案的狗和14只接受单一多次治疗方案的猴子来评估双脱水半乳糖醇的毒性。在狗身上确定了单次注射剂量和每日五次注射的最高无毒、低毒、高毒和致死剂量，在猴子身上确定了每日五次注射的相应剂量。确定了狗的剂量范围为20-320mg/m²（单次注射）和5-80mg/m²（每日五次注射），猴子的剂量范围为3-96mg/m²（每日五次注射）。在每日重复注射中，猴子对低毒剂量比狗更敏感，对高毒剂量更耐受。狗和猴子的剂量反应曲线具有相似的斜率和拐点。由于两个物种的致死剂量和最高无毒剂量之间的斜率都很陡，因此在初始临床试验中应谨慎使用。
