Morris P J, Oliver D, Bishop M, Cullen P, Fellows G, French M, Ledingham J G, Smith J C, Ting A, Williams K
Lancet. 1978;2(8104-5):1353-6. doi: 10.1016/s0140-6736(78)91988-8.
158 kidneys, 9 from living related donors and 149 from cadavers, have been transplanted in the first 42 months of the establishment of a transplant unit at Oxford. Patients' ages ranged from 11 to 56 (mean 35) years. Azathioprine and prednisolone alone were used for immunosuppression, and a minimum-transfusion policy was in operation throughout. After cadaveric transplantation actuarial patient-survival is 70% and 68%, respectively, at the same intervals. 85% of patients who had a functioning graft are fully rehabilitated. Matching for HLA-DR, pregraft blood-transfusions, and the finding that a transplant could be performed in the presence of a positive B-cell crossmatch have proved to be the most significant of the many factors examined both prospectively and retrospectively. The function of the unit is based on dialysis and transplantation for all patients in end-stage renal failure, with transplantation being considered the first line of treatment for patients under the age of 56. The results of transplantation reported here, which have been achieved with conventional immunosuppressive therapy and minimum-transfusion policy, might be considered a standard against which modifications of the practice of renal transplantation can be compared.
在牛津的一个移植单位成立后的头42个月里，共进行了158例肾脏移植手术，其中9例来自活体亲属供体，149例来自尸体供体。患者年龄在11岁至56岁之间（平均35岁）。免疫抑制仅使用硫唑嘌呤和泼尼松龙，并且自始至终都实行最低输血政策。尸体肾移植后，在相同时间间隔下患者的精算生存率分别为70%和68%。85%移植肾功能良好的患者已完全康复。前瞻性和回顾性研究的众多因素中，HLA-DR配型、移植前输血以及在B细胞交叉配型阳性情况下仍可进行移植这一发现被证明是最为重要的因素。该单位的职能是为所有终末期肾衰竭患者提供透析和移植治疗，对于56岁以下的患者，移植被视为一线治疗方法。这里报告的移植结果是在传统免疫抑制疗法和最低输血政策下取得的，可作为比较肾移植实践改进情况的标准。
