一名成人中与t(1;19)(q23;p13)相关的急性淋巴细胞白血病
Acute lymphoblastic leukemia associated with a t(1;19)(q23;p13) in an adult.
作者信息
Ohno H, Inoue T, Akasaka T, Okumura A, Miyanishi S, Ohashi I, Kikuchi M, Masuya M, Amano H, Imanaka T
机构信息
Division of Hematology, Tenri Hospital, Japan.
出版信息
Intern Med. 1993 Jul;32(7):584-7. doi: 10.2169/internalmedicine.32.584.
A cytogenetic study of a 38-year-old patient with acute lymphoblastic leukemia (ALL) revealed a t(1;19)(q23;p13), which is a characteristic translocation of childhood ALL. The leukemic cells were positive for the CD10, CD19, HLA-DR, TdT and cytoplasmic mu-chain. Both of the immunoglobulin heavy chain gene loci were rearranged and the RNA-based polymerase chain reaction demonstrated the E2A/PBX1 fusion transcript which is the result of the t(1;19). This finding suggests that the t(1;19) is implicated not only in childhood ALL but also in adult ALL patients.
对一名38岁急性淋巴细胞白血病（ALL）患者进行的细胞遗传学研究显示存在t(1;19)(q23;p13)，这是儿童ALL的特征性易位。白血病细胞CD10、CD19、HLA-DR、TdT和胞质μ链呈阳性。两个免疫球蛋白重链基因位点均发生重排，基于RNA的聚合酶链反应证实存在E2A/PBX1融合转录本，这是t(1;19)的结果。这一发现表明，t(1;19)不仅与儿童ALL有关，也与成人ALL患者有关。
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